vascular endothelial growth factor a การใช้

• Neuropilin 1 has been shown to interact with Vascular endothelial growth factor A.
• Extracts from " P . campestris " leaves have been shown to inhibit the interaction between Vascular endothelial growth factor A and Vascular endothelial growth factor receptor 1.
• One arm of the antibody binds Angiopoietin-2 ( Ang2 ) and the other is based on bevacizumab ( Avastin ), binding Vascular Endothelial Growth Factor A ( VEGF-A ).
• In July 2016, Moderna and AstraZeneca announced the filing of a clinical trial application for investigational cardiometabolic mRNA drug AZD8601, which encodes for vascular endothelial growth factor A ( VEGF-A ).
• For example, in a mouse myocardial infarction model, a single intramyocardial injection of human vascular endothelial growth factor A mRNA ( VEGF-A modRNA ), modified to escape the body's normal defense system, results in long-term improvement of heart function due to mobilization and redirection of epicardial progenitor cells toward cardiovascular cell types.
• This down regulation was also observed in breast cancer cell lines, including MCF-7 and MDA-MB-231 compared to the non-malignant cell line MCF-10A . It directly targets HER3 receptor, vascular endothelial growth factor A ( VEGF-A ) through interaction with putative binding site in the 3'- untranslated region ( 3'- UTR ) of ErbB3 and VEGF-A . miR-205 inhibits the activation of the downstream mediator Akt . miR-205 was found to be able to interfere with the proliferative pathway mediated by HER receptor family.